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Matthew K. Armstrong

Assistant Professor

Department of Exercise Science

Location

Barclay Hall, #430M
Syracuse, NY 13244

Biography

Matthew Armstrong (he/him/his) joined the Department of Exercise Science in Falk College in the Fall 2024 as an assistant professor and is the director of the Applied Cardiovascular Physiology Lab at Syracuse University.

Before joining to Syracuse University, Armstrong completed an NIH funded postdoctoral fellowship at the University of Iowa (2021–24), where he studied large artery structure and function. He completed his Ph.D. in Australia at the Menzies Institute for Medical Research, University of Tasmania.

Armstrong’s research focuses on cardiovascular disease, with emphasis on blood pressure regulation and vascular dysfunction. His work aims to better understand the mechanisms underlying cardiovascular impairment and to identify biomarkers that predict adverse events. Using hemodynamic modeling approaches to investigate cardiovascular dysfunction in humans comprises the majority of his scholarly output.

Subsequent research exploring the effects of chemotherapy on large artery properties among young cancer survivors has been supported by an Adolescent and Young Adult Research Award. In addition, he leads a funded pilot study applying deep learning to estimate vascular age. In 2022, Armstrong received the Journal of Human Hypertension’s Young Investigator Award.

Education

  • Ph.D., Menzies Institute for Medical Research, University of Tasmania
  • B.Sc., Health Sciences, Cardiff Metropolitan University, . Major: Biomedical Sciences with Health, Exercise & Nutrition

Fellowships

  • Postdoctoral Research Fellow - University of Iowa, Department of Health and Human Physiology, Iowa City, IA, United States

Specialization

  • Cardiovascular physiology and epidemiology, R programming, vascular hemodynamics, pulse wave analysis

Teaching

Notable Courses

EXE 462 - Cardiac Rehabilitation -
EXE 427/627 - Exercise Testing and Interpretation
BIO 460 - Research in Biology,

Currently Teaching

  • EXE 462 - Cardiac Rehabilitation
  • EXE 427 - Exercise Testing and Interpretation
  • BIO 460 - Research in Biology

Active Research

Sponsored Research

  • Matthew Armstrong (PD/PI) Brooks Gump (Co-PD/PI) , Characterizing Treatment-Related Hemodynamic and Vascular Changes Associated with Heart Failure Among Cancer Survivors - American Heart Association - Not for Profit/Foundation. End Date: 2029-03-31

Other Grants, Fellowships, Contracts, and Gifts

  • Matthew Armstrong (PD/PI), Assessment of Vascular Ageing - Syracuse Office of Undergraduate Research & Creative Engagement (SOURCE) Research Assistant Grant. End Date: 2026-08-31

Published Scholarship

Publications

  • Picone, D.S., Schultz, M.G., Armstrong, M.K., Black, J.A., Dwyer, N., Roberts-Thomson, P., Weber, T. and Sharman, J.E., 2025. Mean arterial pressure differences between cuff oscillometric and invasive blood pressure. Hypertension Research, [online] 48(5), pp.1749–1758. https://doi.org/10.1038/s41440-025-02165-4.
  • Evans, J.T., Buscot, M.-J., Fraser, B.J., Juonala, M., Guo, Y., Fernandez, C., Kähönen, M., Sabin, M.A., Armstrong, M.K., Viikari, J.S.A., Bazzano, L.A., Raitakari, O.T. and Magnussen, C.G., 2024. Life-period associations of body mass index with adult carotid intima-media thickness: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study. Preventive Medicine, [online] 189, p.108128. https://doi.org/10.1016/j.ypmed.2024.108128.
  • Armstrong, M.K., Jain, S., Nuckols, V., Pewowaruk, R., Zhang, X., DuBose, L., Sodoma, M., Madero, B., Voss, M.W. and Pierce, G.L., 2024. The association of structural versus load-dependent large artery stiffness mechanisms with cerebrovascular damage and cortical atrophy in humans. GeroScience, [online] 46(6), pp.5587–5597. https://doi.org/10.1007/s11357-024-01254-5.
  • Stanesby, O., Armstrong, M.K., Otahal, P., Goode, J.P., Fraser, B.J., Negishi, K., Kidokoro, T., Winzenberg, T., Juonala, M., Wu, F., Kelly, R.K., Xi, B., Viikari, J.S.A., Raitakari, O.T., Daniels, S.R., Tomkinson, G.R. and Magnussen, C.G., 2024. Tracking of serum lipid levels from childhood to adulthood: Systematic review and meta-analysis. Atherosclerosis, [online] 391, p.117482. https://doi.org/10.1016/j.atherosclerosis.2024.117482.
  • Armstrong, M.K., Nuckols, V.R., Gimblet, C.J., Holwerda, S.W., DuBose, L.E., Luehrs, R.E., Lane, A.D., Chirinos, J.A., Voss, M.W. and Pierce, G.L., 2023. Relation of forward and backward traveling pressure waves with subclinical carotid artery wall remodeling and central pulse pressure. Journal of Applied Physiology, [online] 135(4), pp.943–949. https://doi.org/10.1152/japplphysiol.00286.2023.
  • Bui, T.V., Picone, D.S., Schultz, M.G., Armstrong, M.K., Peng, X., Black, J.A., Dwyer, N., Roberts-Thomson, P., Adams, H., Hughes, A.D. and Sharman, J.E., 2022. Comparison between cuff-based and invasive systolic blood pressure amplification. Journal of Hypertension, [online] 40(10), pp.2037–2044. https://doi.org/10.1097/hjh.0000000000003228.
  • Armstrong, M.K., Chirinos, J.A., Kapuku, G.K. and Pierce, G.L., 2022. Aortic pressure-only wave separation analysis in adolescents: accuracy and associations with left ventricular mass index. Journal of Human Hypertension, [online] 37(12), pp.1119–1125. https://doi.org/10.1038/s41371-022-00757-y.
  • Armstrong, M.K., Fraser, B.J., Hartiala, O., Buscot, M.-J., Juonala, M., Wu, F., Koskinen, J., Hutri-Kähönen, N., Kähönen, M., Laitinen, T.P., Lehtimäki, T., Viikari, J.S.A., Raitakari, O.T. and Magnussen, C.G., 2021. Association of Non–High-Density Lipoprotein Cholesterol Measured in Adolescence, Young Adulthood, and Mid-Adulthood With Coronary Artery Calcification Measured in Mid-Adulthood. JAMA Cardiology, [online] 6(6), p.661. https://doi.org/10.1001/jamacardio.2020.7238.
  • Schultz, M.G., Picone, D.S., Armstrong, M.K., Black, J.A., Dwyer, N., Roberts-Thomson, P. and Sharman, J.E., 2020. Validation Study to Determine the Accuracy of Central Blood Pressure Measurement Using the Sphygmocor Xcel Cuff Device. Hypertension, [online] 76(1), pp.244–250. https://doi.org/10.1161/hypertensionaha.120.14916.
  • Armstrong, M.K., Schultz, M.G., Picone, D.S., Black, J.A., Dwyer, N., Roberts-Thomson, P. and Sharman, J.E., 2019. Brachial and Radial Systolic Blood Pressure Are Not the Same. Hypertension, [online] 73(5), pp.1036–1041. https://doi.org/10.1161/hypertensionaha.119.12674.

Presentations

  • Armstrong, M.K., 2025. 24 h physical behaviors composition in US adults aged 40-64 years: NHANES 2011-2014. In Mid Atlantic Chapter of ACSM.
  • Armstrong, M.K., 2025. Agreement between self-reported and accelerometer derived nocturnal sleep durations. In Mid Atlantic Chapter of ACSM.
  • Armstrong, M.K., 2025. Aortic-brachial stiffness ratio is elevated among adolescent and young adult cancer survivors post anthracycline therapy. In Smilow Center for Translational Research. North American ARTERY.
  • Armstrong, M.K., 2025. Large artery structure, function, and hemodynamics. In Smilow Center for Translational Research. North American ARTERY.
  • Armstrong, M.K., 2025. Stanly Franklin Debate: GLP-1 Agonists Improve Cardiovascular Health Through Vascular Mechanisms. In Smilow Center for Translational Research. North American ARTERY.
  • Armstrong, M.K., 2025. Higher Backward Central Pressure and Pulse Pressure Among Women With a History of Preeclampsia: Role of Central Pulsatile Pressure Hemodynamics on Cognitive Function. In American Physiology Summit.
  • Armstrong, M.K., 2025. The effect of sublingual nitroglycerin on aortic hemodynamics and exercise cardiac reserve in adults with heart failure with preserved ejection fraction. In American Physiology Summit.
  • Armstrong, M.K., 2025. Vascular consequences post anthracycline therapy. In Holden Cancer Centre. Adolescent and Young Adult Cancer Symposium. University of Iowa.
  • Armstrong, M.K., 2024. The Association of Structural Versus Load-Dependent Large Artery Stiffness Mechanisms with Cerebrovascular Damage and Cortical Atrophy in Humans. In North American ARTERY.
  • Armstrong, M.K., 2023. Association of Large Artery Reservoir Function with Cerebral Total, Periventricular, and Deep White Matter Lesions. In American Heart Association.

Active Service

Professional Service

  • Committee Member, Young Investigator Committee, North American Association for Research into Arterial Structure and Physiology (active since: 2023)

Honors, Awards, and Recognition

  • Journal of Human Hypertension Young Investigator Award 2022, Journal of Human Hypertension
  • Ten of the Best Award, Menzies Institute for Medical Research
  • Excelences in Post Graduate Research Award, Australian Society for Medical Research
  • Dr. J. Marsden Award for Excellence in Physiology, Cardiff Metropolitan University
  • Effective Communication Award, Cardiff Metropolitan University

Memberships

  • American Heart Association
  • American Physiological Society
  • North American ARTERY

Recent Media Mentions:

  • Cholesterol and coronary artery calcification (15 February 2021)

Location

Barclay Hall, #430M
Syracuse, NY 13244